dc.contributor.author
Munz, Matthias
dc.contributor.author
Richter, Gesa M.
dc.contributor.author
Loos, Bruno G.
dc.contributor.author
Jepsen, Søren
dc.contributor.author
Divaris, Kimon
dc.contributor.author
Offenbacher, Steven
dc.contributor.author
Teumer, Alexander
dc.contributor.author
Holtfreter, Birte
dc.contributor.author
Kocher, Thomas
dc.contributor.author
Bruckmann, Corinna
dc.contributor.author
Jockel-Schneider, Yvonne
dc.contributor.author
Graetz, Christian
dc.contributor.author
Munoz, Loreto
dc.contributor.author
Bhandari, Anita
dc.contributor.author
Tennstedt, Stephanie
dc.contributor.author
Staufenbiel, Ingmar
dc.contributor.author
Velde, Nathalie van der
dc.contributor.author
Uitterlinden, André G.
dc.contributor.author
Groot, Lisette C. P. G. M. de
dc.contributor.author
Wellmann, Jürgen
dc.contributor.author
Berger, Klaus
dc.contributor.author
Krone, Bastian
dc.contributor.author
Hoffmann, Per
dc.contributor.author
Laudes, Matthias
dc.contributor.author
Lieb, Wolfgang
dc.contributor.author
Franke, Andre
dc.contributor.author
Dommisch, Henrik
dc.contributor.author
Erdmann, Jeanette
dc.contributor.author
Schaefer, Arne S.
dc.date.accessioned
2019-04-10T11:33:33Z
dc.date.available
2019-04-10T11:33:33Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24351
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2123
dc.description.abstract
Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned selection criteria (PAgP-Ger < 0.05; PCAD < 5 × 10−8; concordant effect direction) and were replicated in an independent GWAS meta-analysis dataset of PD (4,415 cases vs 5,935 controls). SNP rs1561198 showed significant association (PD[Replication]: P = 0.008 OR = 1.09, 95% CI = [1.02–1.16]; PD [Discovery + Replication]: P = 0.0002, OR = 1.11, 95% CI = [1.05–1.17]). For the associated haplotype block, allele specific cis-effects on VAMP8 expression were reported. Our data adds to the shared genetic basis of CAD and PD and indicate that the observed association of the two disease conditions cannot be solely explained by shared environmental risk factors. We conclude that the molecular pathway shared by CAD and PD involves VAMP8 function, which has a role in membrane vesicular trafficking, and is manipulated by pathogens to corrupt host immune defense.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
coronary artery disease (CAD)
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
13678
dcterms.bibliographicCitation.doi
10.1038/s41598-018-31980-8
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Nature Publishing Group
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30209331
dcterms.isPartOf.issn
2045-2322