dc.contributor.author
Mann, Constanze
dc.contributor.author
Ziegeler, Katharina
dc.contributor.author
Mews, Jürgen
dc.contributor.author
Plaschke, Martina
dc.contributor.author
Issever, Ahi Sema
dc.date.accessioned
2019-04-03T10:15:22Z
dc.date.available
2019-04-03T10:15:22Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24285
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2057
dc.description.abstract
This study examines the influence of iterative reconstruction on bone mineral density (BMD) measurement by comparison with standard quantitative computed tomography (QCT; reference) and two other protocols based on filtered back projection. Ten human cadaver specimens of the lumbar spine with a hydroxyapatite calibration phantom underneath, were scanned with 4 protocols: 1. standard QCT, 2. volume scan with FBP, 3. helical scan with FBP, and 4. helical scan with IR (Adaptive Iterative Dose Reduction 3D (AIDR3D)). Radiation doses were recorded as CT dose index (CTDIvol) and BMD, signal-to-noise and contrast-to-noise ratio were calculated. Mean hydroxyapatite concentration (HOA) did not differ significantly between protocols, ranging from 98.58 ± 31.09 mg cm3 (protocol 4) to 100.47 ± 30.82 mg cm3 (protocol 2). Paired sample correlations of HOA values for protocol 4 and protocols 1, 2 and 3 were nearly perfect with coefficients of 0.980, 0.979 and 0.982, respectively (p < 0.004). CTDIvol were 7.50, 5.00, 6.82 (±2.03) and 1.72 (±0.50) mGy for protocols 1, 2, 3 and 4 respectively. Objective image quality was highest for protocol 4. The use of IR for BMD assessment significantly lowers radiation exposure compared to standard QCT and protocols with FBP while not degrading BMD measurement.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
bone mineral density
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Bone mineral density assessment using iterative reconstruction compared with quantitative computed tomography as the standard of reference
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
15095
dcterms.bibliographicCitation.doi
10.1038/s41598-018-33444-5
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Nature Publishing Group
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30305658
dcterms.isPartOf.issn
2045-2322