dc.contributor.author
Gehle, Petra
dc.contributor.author
Goergen, Barbara
dc.contributor.author
Pilger, Daniel
dc.contributor.author
Ruokonen, Peter
dc.contributor.author
Robinson, Peter N.
dc.contributor.author
Salchow, Daniel J.
dc.date.accessioned
2018-06-08T11:07:29Z
dc.date.available
2017-10-23T10:57:24.102Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21661
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24949
dc.description.abstract
Background To study biometric and structural ocular manifestations of Marfan
syndrome (MFS). Methods Observational, retrospective, comparative cohort study
in a tertiary referral center on 285 MFS patients and 267 controls. Structural
and biometric ocular characteristic were compared. Results MFS eyes were
longer (axial length 24.25 ± 1.74 mm versus 23.89 ± 1.31 mm, p < 0.001) and
had a flatter cornea than control eyes (mean keratometry 41.78 ± 1.80 diopters
(D) versus 43.05 ± 1.51 D, p < 0.001). Corneal astigmatism was greater and the
central cornea was thinner in MFS eyes (530.14 ± 41.31 μm versus 547.02 ±
39.18 μm, p < 0.001). MFS eyes were more myopic than control eyes (spherical
equivalent -2.16 ± 3.75 D versus -1.17 ± 2.58 D, p < 0.001). Visual acuity was
reduced (0.13 ± 0.25 logMAR versus 0.05 ± 0.18 logMAR, p < 0.001) and
intraocular pressure was lower in MFS eyes (14.6 ± 3.4 mmHg versus 15.1 ± 3.2
mmHg, p = 0.01). Iris transillumination defects (ITD) were significantly more
common in MFS eyes (odds ratio for MFS in the presence of ITD, 3.7). Ectopia
lentis (EL) was only present in MFS eyes (33.4%). History of retinal
detachment was significantly more common in MFS eyes. Glaucoma was equally
common in both groups. Conclusions ITD and EL are most characteristic findings
in MFS. ITD and corneal curvature should be studied as diagnostic criteria for
MFS. Visual acuity is reduced in MFS. MFS patients need regular eye exams to
identify serious ocular complications.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Biometric and structural ocular manifestations of Marfan syndrome
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 12 (2017), 9, Artikel Nr. e0183370
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0183370
dcterms.bibliographicCitation.url
http://doi.org/10.1371/journal.pone.0183370
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000028361
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009029
dcterms.accessRights.openaire
open access