dc.contributor.author
Azab, Walid
dc.contributor.author
El-Sheikh, Abuelyazeed
dc.date.accessioned
2018-06-08T11:01:37Z
dc.date.available
2018-01-25T11:33:31.071Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21484
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24776
dc.description.abstract
Equine herpesvirus 4 (EHV-4) is an important equine pathogen that causes
respiratory tract disease among horses worldwide. Glycoprotein K (gK)
homologues have been identified in several alphaherpesviruses as a major
player in virus entry, replication, and spread. In the present study, EHV-4
gK-deletion mutant has been generated by using bacterial artificial chromosome
technology and Red mutagenesis to investigate the role of gK in EHV-4
replication. Our findings reported here show that gK is essential for virus
replication in vitro and that the gK-negative strain was not able to be
reconstituted in equine cells. It is noteworthy that these findings agree with
the previously published study describing gK deletion in other
alphaherpesviruses. View Full-Text
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft
dc.title
The Role of Equine Herpesvirus Type 4 Glycoprotein K in Virus Replication
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Viruses. - 4 (2012), 8, S. 1258-1263
dcterms.bibliographicCitation.doi
10.3390/v4081258
dcterms.bibliographicCitation.url
http://www.mdpi.com/1999-4915/4/8/1258
refubium.affiliation
Veterinärmedizin
de
refubium.mycore.fudocsId
FUDOCS_document_000000028872
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009366
dcterms.accessRights.openaire
open access