dc.contributor.author
Unbehauen, Michael L.
dc.contributor.author
Fleige, Emanuel
dc.contributor.author
Paulus, Florian
dc.contributor.author
Schemmer, Brigitta
dc.contributor.author
Mecking, Stefan
dc.contributor.author
More, Sam Dylan
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2018-06-08T10:54:31Z
dc.date.available
2017-10-12T10:10:22.254Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21308
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24603
dc.description.abstract
We here present the synthesis and characterization of a set of biodegradable
core–multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of
hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18,
19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG)
outer shell that were conjugated by ester bonds only to reduce the toxicity of
metabolites. The loading capacities (LC) of the drugs, dexamethasone and
tacrolimus, and the aggregate formation, phase transitions, and degradation
kinetics were determined. The intermediate inner shell length (C15) system had
the best overall performance with good LCs for both drugs as well as a
promising degradation and release kinetics, which are of interest for dermal
delivery
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
biodegradable CMS nanocarrier
dc.subject
dendritic polymers
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie
dc.title
Biodegradable Core–Multishell Nanocarriers
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Polymers. - 9 (2017), 8, Artkel Nr. 316
dc.title.subtitle
Influence of Inner Shell Structure on the Encapsulation Behavior of
Dexamethasone and Tacrolimus
dcterms.bibliographicCitation.doi
10.3390/polym9080316
dcterms.bibliographicCitation.url
http://www.mdpi.com/2073-4360/9/8/316
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000028293
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008971
dcterms.accessRights.openaire
open access