dc.contributor.author
Kaiser, Tobias S.
dc.contributor.author
Poehn, Birgit
dc.contributor.author
Szkiba, David
dc.contributor.author
Preußner, Marco
dc.contributor.author
Sedlazeck, Fritz J.
dc.contributor.author
Zrim, Alexander
dc.contributor.author
Neumann, Tobias
dc.contributor.author
Nguyen, Lam-Tung
dc.contributor.author
Betancourt, Andrea J.
dc.contributor.author
Hummel, Thomas
dc.contributor.author
Vogel, Heiko
dc.contributor.author
Dorner, Silke
dc.contributor.author
Heyd, Florian
dc.contributor.author
von Haeseler, Arndt von
dc.contributor.author
Tessmar-Raible, Kristin
dc.date.accessioned
2018-06-08T10:49:23Z
dc.date.available
2017-06-23T10:08:24.956Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21158
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24455
dc.description.abstract
Organisms use endogenous clocks to anticipate regular environmental cycles,
such as days and tides. Natural variants resulting in differently timed
behaviour or physiology, known as chronotypes in humans, have not been well
characterized at the molecular level. We sequenced the genome of Clunio
marinus, a marine midge whose reproduction is timed by circadian and
circalunar clocks. Midges from different locations show strain-specific
genetic timing adaptations. We examined genetic variation in five C. marinus
strains from different locations and mapped quantitative trait loci for
circalunar and circadian chronotypes. The region most strongly associated with
circadian chronotypes generates strain-specific differences in the abundance
of calcium/calmodulin-dependent kinase II.1 (CaMKII.1) splice variants. As
equivalent variants were shown to alter CaMKII activity in Drosophila
melanogaster, and C. marinus (Cma)-CaMKII.1 increases the transcriptional
activity of the dimer of the circadian proteins Cma-CLOCK and Cma-CYCLE, we
suggest that modulation of alternative splicing is a mechanism for natural
adaptation in circadian timing.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Evolutionary genetics
dc.subject
Ecological genetics
dc.subject
Circadian regulation
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.title
The genomic basis of circadian and circalunar timing adaptations in a midge
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Nature. - 540 (2016), 7631, S.69-73
dc.identifier.sepid
55960
dcterms.bibliographicCitation.doi
10.1038/nature20151
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1038/nature20151
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000027230
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008359
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
0028-0836