dc.contributor.author
Laenen, Lies
dc.contributor.author
Vergote, Valentijn
dc.contributor.author
Kafetzopoulou, Liana Eleni
dc.contributor.author
Wawina, Tony Bokalanga
dc.contributor.author
Vassou, Despoina
dc.contributor.author
Cook, Joseph A.
dc.contributor.author
Hugot, Jean-Pierre
dc.contributor.author
Deboutte, Ward
dc.contributor.author
Kang, Hae Ji
dc.contributor.author
Witkowski, Peter T.
dc.contributor.author
Köppen-Rung, Panja
dc.contributor.author
Krüger, Detlev H.
dc.date.accessioned
2018-06-08T10:45:25Z
dc.date.available
2018-03-22T13:00:38.864Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21029
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24326
dc.description.abstract
Hantaviruses are zoonotic viruses with a complex evolutionary history of
virus–host coevolution and cross-species transmission. Although hantaviruses
have a broad reservoir host range, virus–host relationships were previously
thought to be strict, with a single virus species infecting a single host
species. Here, we describe Bruges virus, a novel hantavirus harbored by the
European mole (Talpa europaea), which is the well-known host of Nova virus.
Phylogenetic analyses of all three genomic segments showed tree topology
inconsistencies, suggesting that Bruges virus has emerged from cross-species
transmission and ancient reassortment events. A high number of coinfections
with Bruges and Nova viruses was detected, but no evidence was found for
reassortment between these two hantaviruses. These findings highlight the
complexity of hantavirus evolution and the importance of further investigation
of hantavirus–reservoir relationships.
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Bruges orthohantavirus
dc.subject
Talpa europaea
dc.subject
virus–host interaction
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
A Novel Hantavirus of the European Mole, Bruges Virus, Is Involved in Frequent
Nova Virus Coinfections
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Genome Biology and Evolution. - 10 (2017), 1, S. 45-55
dcterms.bibliographicCitation.doi
10.1093/gbe/evx268
dcterms.bibliographicCitation.url
http://doi.org/10.1093/gbe/evx268
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000029383
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009572
dcterms.accessRights.openaire
open access