Title:
1,3-Dibromo-5,5-dimethylhydantoin as promoter for glycosylations using
thioglycosides
Author(s):
Xu, Fei-Fei; Pereira, Claney L.; Seeberger, Peter H.
Year of publication:
2017
Available Date:
2017-10-18T11:43:05.098Z
Abstract:
1,3-Dibromo-5,5-dimethylhydantoin (DBDMH), an inexpensive, non-toxic and
stable reagent, is a competent activator of thioglycosides for glycosidic bond
formation. Excellent yields were obtained when triflic acid (TfOH) or
trimethylsilyl trifluoromethanesulfonate (TMSOTf) were employed as co-
promoters in solution or automated glycan assembly on solid phase.
Keywords:
automated glycan assembly
1,3-dibromo-5,5-dimethylhydantoin
glycosylation
promoter
thioglycosides
DDC-Classification:
540 Chemie
Publication Type:
Wissenschaftlicher Artikel
Also published in:
Beilstein J. Org. Chem. - 13 (2017), S. 1994-1998
URL of the Original Publication:
DOI of the Original Publication:
Department/institution:
Biologie, Chemie, Pharmazie
Comments:
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
