dc.contributor.author
Cerda-Esteban, Nuria
dc.contributor.author
Naumann, Heike
dc.contributor.author
Ruzittu, Silvia
dc.contributor.author
Mah, Nancy
dc.contributor.author
Pongrac, Igor M.
dc.contributor.author
Cozzitorto, Corinna
dc.contributor.author
Hommel, Angela
dc.contributor.author
Andrade-Navarro, Miguel A.
dc.contributor.author
Bonifacio, Ezio
dc.contributor.author
Spagnoli, Francesca M.
dc.date.accessioned
2018-06-08T10:40:03Z
dc.date.available
2017-04-24T11:28:44.397Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20849
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24148
dc.description.abstract
The development of a successful lineage reprogramming strategy of liver to
pancreas holds promises for the treatment and potential cure of diabetes. The
liver is an ideal tissue source for generating pancreatic cells, because of
its close developmental origin with the pancreas and its regenerative ability.
Yet, the molecular bases of hepatic and pancreatic cellular plasticity are
still poorly understood. Here, we report that the TALE homeoprotein TGIF2 acts
as a developmental regulator of the pancreas versus liver fate decision and is
sufficient to elicit liver-to-pancreas fate conversion both ex vivo and in
vivo. Hepatocytes expressing Tgif2 undergo extensive transcriptional
remodelling, which represses the original hepatic identity and, over time,
induces a pancreatic progenitor-like phenotype. Consistently, in vivo forced
expression of Tgif2 activates pancreatic progenitor genes in adult mouse
hepatocytes. This study uncovers the reprogramming activity of TGIF2 and
suggests a stepwise reprogramming paradigm, whereby a ‘lineage-restricted’
dedifferentiation step precedes the identity switch.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Transdifferentiation
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Stepwise reprogramming of liver cells to a pancreas progenitor state by the
transcriptional regulator Tgif2
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Nature Communications. - 8 (2017), Artikel Nr. 14127
dcterms.bibliographicCitation.doi
10.1038/ncomms14127
dcterms.bibliographicCitation.url
http://www.nature.com/articles/ncomms14127
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000026864
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008083
dcterms.accessRights.openaire
open access