dc.contributor.author
Wallmeyer, Leonie
dc.contributor.author
Dietert, Kristina
dc.contributor.author
Sochorová, Michaela
dc.contributor.author
Gruber, Achim D.
dc.contributor.author
Kleuser, Burkhard
dc.contributor.author
Vávrová, Kateřina
dc.contributor.author
Hedtrich, Sarah
dc.date.accessioned
2018-06-08T10:35:55Z
dc.date.available
2017-05-23T10:41:53.859Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20705
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24005
dc.description.abstract
Mutations in the gene encoding for filaggrin (FLG) are major predisposing
factors for atopic dermatitis (AD). Besides genetic predisposition,
immunological dysregulations considerably contribute to its pathophysiology.
For example, thymic stromal lymphopoietin (TSLP) is highly expressed in
lesional atopic skin and significantly contributes to the pathogenesis of AD
by activating dendritic cells that then initiate downstream effects on, for
example, T cells. However, little is known about the direct interplay between
TSLP, filaggrin-deficient skin and other immune cells such as T lymphocytes.
In the present study, FLG knockdown skin equivalents, characterised by
intrinsically high TSLP levels, were exposed to activated CD4+ T cells. T cell
exposure resulted in an inflammatory phenotype of the skin equivalents.
Furthermore, a distinct shift from a Th1/Th17 to a Th2/Th22 profile was
observed following exposure of T cells to filaggrin-deficient skin
equivalents. Interestingly, TSLP directly stimulated T cell migration
exclusively in filaggrin-deficient skin equivalents even in the absence of
dendritic cells, indicating a hitherto unknown role of TSLP in the
pathogenesis of AD.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
TSLP is a direct trigger for T cell migration in filaggrin-deficient skin
equivalents
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 7 (2017), Artikel Nr. 774
dcterms.bibliographicCitation.doi
10.1038/s41598-017-00670-2
dcterms.bibliographicCitation.url
http://www.nature.com/articles/s41598-017-00670-2
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.funding
Deutsche Forschungsgemeinschaft (DFG)
refubium.funding.id
02500
refubium.mycore.fudocsId
FUDOCS_document_000000027050
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008226
dcterms.accessRights.openaire
open access