dc.contributor.author
Suzuki, Mototaka
dc.contributor.author
Larkum, Matthew E.
dc.date.accessioned
2018-06-08T10:34:36Z
dc.date.available
2017-10-06T08:50:32.745Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20683
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23983
dc.description.abstract
Cortical surface recording techniques such as EEG and ECoG are widely used for
measuring brain activity. The prevailing assumption is that surface potentials
primarily reflect synaptic activity, although non-synaptic events may also
contribute. Here we show that dendritic calcium spikes occurring in pyramidal
neurons (that we showed previously are cognitively relevant) are clearly
detectable in cortical surface potentials. To show this we developed an
optogenetic, non-synaptic approach to evoke dendritic calcium spikes in vivo.
We found that optogenetically evoked calcium spikes were easily detectable and
had an unexpected waveform near the cortical surface. Sensory-evoked dendritic
calcium spikes were also clearly detectable with amplitudes that matched the
contribution of synaptic input. These results reveal how dendritic calcium
spikes appear at the cortical surface and their significant impact on surface
potentials, suggesting that long-standing surface recording data may contain
information about dendritic activity that is relevant to behavior and
cognitive function.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Dendritic calcium spikes are clearly detectable at the cortical surface
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Nature Communications. - 8 (2017), Artikel Nr. 276
dcterms.bibliographicCitation.doi
10.1038/s41467-017-00282-4
dcterms.bibliographicCitation.url
http://www.nature.com/articles/s41467-017-00282-4
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000028156
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-HZeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008855
dcterms.accessRights.openaire
open access