dc.contributor.author
Lee, Cheng-Ta
dc.contributor.author
Kao, Min-Hua
dc.contributor.author
Hou, Wen-Hsien
dc.contributor.author
Wei, Yu-Ting
dc.contributor.author
Chen, Chin-Lin
dc.contributor.author
Lien, Cheng-Chang
dc.date.accessioned
2018-06-08T10:33:20Z
dc.date.available
2017-01-10T10:00:38.021Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20646
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23947
dc.description.abstract
The dentate gyrus (DG) is the primary gate of the hippocampus and controls
information flow from the cortex to the hippocampus proper. To maintain normal
function, granule cells (GCs), the principal neurons in the DG, receive fine-
tuned inhibition from local-circuit GABAergic inhibitory interneurons (INs).
Abnormalities of GABAergic circuits in the DG are associated with several
brain disorders, including epilepsy, autism, schizophrenia, and Alzheimer
disease. Therefore, understanding the network mechanisms of inhibitory control
of GCs is of functional and pathophysiological importance. GABAergic
inhibitory INs are heterogeneous, but it is unclear how individual subtypes
contribute to GC activity. Using cell-type-specific optogenetic perturbation,
we investigated whether and how two major IN populations defined by
parvalbumin (PV) and somatostatin (SST) expression, regulate GC input
transformations. We showed that PV-expressing (PV+) INs, and not SST-
expressing (SST+) INs, primarily suppress GC responses to single cortical
stimulation. In addition, these two IN classes differentially regulate GC
responses to θ and γ frequency inputs from the cortex. Notably, PV+ INs
specifically control the onset of the spike series, whereas SST+ INs
preferentially regulate the later spikes in the series. Together, PV+ and SST+
GABAergic INs engage differentially in GC input-output transformations in
response to various activity patterns.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Neural circuits
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Causal Evidence for the Role of Specific GABAergic Interneuron Types in
Entorhinal Recruitment of Dentate Granule Cells
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 6 (2016), Artikel Nr. 36885
dcterms.bibliographicCitation.doi
10.1038/srep36885
dcterms.bibliographicCitation.url
http://www.nature.com/articles/srep36885
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000026114
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007502
dcterms.accessRights.openaire
open access