dc.contributor.author
Baumann, Veronika J.
dc.contributor.author
Lehnert, Simon
dc.contributor.author
Leibold, Christian
dc.contributor.author
Koch, Ursula
dc.date.accessioned
2018-06-08T10:22:55Z
dc.date.available
2018-01-23T13:38:59.725Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20340
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23643
dc.description.abstract
Neuronal membrane properties can largely vary even within distinct
morphological cell classes. The mechanisms and functional consequences of this
diversity, however, are little explored. In the medial superior olive (MSO), a
brainstem nucleus that performs binaural coincidence detection, membrane
properties at rest are largely governed by the hyperpolarization-activated
inward current (Ih) which enables the temporally precise integration of
excitatory and inhibitory inputs. Here, we report that Ih density varies along
the putative tonotopic axis of the MSO with Ih being largest in ventral, high-
frequency (HF) processing neurons. Also Ih half-maximal activation voltage and
time constant are differentially distributed such that Ih of the putative HF
processing neurons activate faster and at more depolarized levels.
Intracellular application of saturating concentrations of cyclic AMP removed
the regional difference in hyperpolarization-activated cyclic nucleotide gated
(HCN) channel activation, but not Ih density. Experimental data in conjunction
with a computational model suggest that increased Ih levels are helpful in
counteracting temporal summation of phase-locked inhibitory inputs which is
particularly prominent in HF neurons.
en
dc.format.extent
14 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject
medial superior olive
dc.subject
sound localization
dc.subject
coincidence detection
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::572 Biochemie
dc.title
Tonotopic organization of the hyperpolarization-activated current (Ih) in the
mammalian medial superior olive
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Frontiers in Neural Circuits 7 (2013), Art. 117
dcterms.bibliographicCitation.doi
10.3389/fncir.2013.00117
dcterms.bibliographicCitation.url
http://doi.org/10.3389/fncir.2013.00117
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.affiliation.other
Institut für Biologie
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refubium.mycore.fudocsId
FUDOCS_document_000000028855
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009359
dcterms.accessRights.openaire
open access