dc.contributor.author
Kronimus, Yannick
dc.contributor.author
Albus, Alexandra
dc.contributor.author
Balzer-Geldsetzer, Monika
dc.contributor.author
Straub, Sarah
dc.contributor.author
Semler, Elisa
dc.contributor.author
Otto, Markus
dc.contributor.author
Klotsche, Jens
dc.contributor.author
Dodel, Richard
dc.contributor.author
Mengel, David
dc.date.accessioned
2018-06-08T10:20:24Z
dc.date.available
2016-12-13T11:50:18.147Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20269
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23573
dc.description.abstract
Background and Objective Altered levels of naturally occurring autoantibodies
(nAbs) against disease-associated neuronal proteins have been reported for
neurodegenerative diseases, such as Alzheimer's (AD) and Parkinson's disease
(PD). Recent histopathologic studies suggest a contribution of both Lewy body-
and AD-related pathology to Parkinson's disease dementia (PDD). Therefore, we
explored nAbs against alpha-synuclein (αS), tau and β-amyloid (Aβ) in PDD
compared to cognitively normal PD patients. Materials and Methods We
established three different ELISAs to quantify the nAbs-tau, nAbs-αS, and
nAbs-Aβ levels and avidity towards their specific antigen in serum samples of
18 non-demented (PDND) and 18 demented PD patients (PDD), which were taken
from an ongoing multi-center cohort study (DEMPARK/LANDSCAPE). Results PDD
patients had significantly decreased nAbs-tau serum levels compared to PDND
patients (p = 0.007), whereas the serum titers of nAbs-αS and nAbs-Aβ were
unchanged. For all three nAbs, no significant differences in avidity were
found between PDD and PDND cohorts. However, within both patient groups, nAbs-
tau showed lowest avidity to their antigen, followed by nAbs-αS, and nAbs-Aβ.
Though, due to a high interassay coefficient of variability and the exclusion
of many samples below the limit of detection, conclusions for nAbs-Aβ are only
conditionally possible. Conclusion We detected a significantly decreased nAbs-
tau serum level in PDD patients, indicating a potential linkage between nAbs-
tau serum titer and cognitive deficits in PD. Thus, further investigation in
larger samples is justified to confirm our findings.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Naturally Occurring Autoantibodies against Tau Protein Are Reduced in
Parkinson's Disease Dementia
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 11 (2016), 11, Artikel Nr. e0164953
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0164953
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pone.0164953
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000026029
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007433
dcterms.accessRights.openaire
open access