Title:
Significantly enhanced proteolytic activity of cyclen complexes by
monoalkylation
Author(s):
Perera-Bobusch, Chrischani; Hormann, Jan; Weise, Christoph; Wedepohl, Stefanie; Dernedde, Jens; Kulak, Nora
Year of publication:
2016
Available Date:
2016-08-08T09:01:47.863Z
Abstract:
A simple approach towards efficient artificial proteases based on the cyclen
ligand is presented. We thus achieved an increase of the proteolytic activity
of two orders of magnitude when compared to the unsubstituted cyclen complex.
Amphiphilic Cu(II) and Co(III) complexes cut BSA and myoglobin as model
substrates at μM concentrations. MALDI-ToF MS is used to identify the cleavage
fragments.
DDC-Classification:
540 Chemie
Publication Type:
Wissenschaftlicher Artikel
Also published in:
Dalton Transactions. - 45 (2016), 26, S. 10500-10504
URL of the Original Publication:
DOI of the Original Publication:
Department/institution:
Biologie, Chemie, Pharmazie
