dc.contributor.author
Doltra, Adelina
dc.contributor.author
Hartmann, Arthur
dc.contributor.author
Stawowy, Philipp
dc.contributor.author
Goubergrits, Leonid
dc.contributor.author
Kuehne, Titus
dc.contributor.author
Wellnhofer, Ernst
dc.contributor.author
Gebker, Rolf
dc.contributor.author
Schneeweis, Christopher
dc.contributor.author
Schnackenburg, Bernhard
dc.contributor.author
Esler, Murray
dc.contributor.author
Fleck, Eckart
dc.contributor.author
Kelle, Sebastian
dc.date.accessioned
2018-06-08T04:09:31Z
dc.date.available
2016-04-18T12:10:56.669Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16693
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20874
dc.description.abstract
Aim To study the effects of RD on renal artery wall function non-invasively
using magnetic resonance. Methods and Results 32 patients undergoing RD were
included. A 3.0 Tesla magnetic resonance of the renal arteries was performed
before RD and after 6-month. We quantified the vessel sharpness of both renal
arteries using a quantitative analysis tool (Soap-Bubble®). In 17 patients we
assessed the maximal and minimal cross-sectional area of both arteries, peak
velocity, mean flow, and renal artery distensibility. In a subset of patients
wall shear stress was assessed with computational flow dynamics. Neither renal
artery sharpness nor renal artery distensibility differed significantly. A
significant increase in minimal and maximal areas (by 25.3%, p = 0.008, and
24.6%, p = 0.007, respectively), peak velocity (by 16.9%, p = 0.021), and mean
flow (by 22.4%, p = 0.007) was observed after RD. Wall shear stress
significantly decreased (by 25%, p = 0.029). These effects were observed in
blood pressure responders and non-responders. Conclusions RD is not associated
with adverse effects at renal artery level, and leads to an increase in cross-
sectional areas, velocity and flow and a decrease in wall shear stress.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Effects of Renal Denervation on Renal Artery Function in Humans: Preliminary
Study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 11 (2016), 3, Artikel Nr. e0150662
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0150662
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pone.0150662
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024396
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006298
dcterms.accessRights.openaire
open access