dc.contributor.author
Dogbevia, Godwin K.
dc.contributor.author
Marticorena-Alvarez, Ricardo
dc.contributor.author
Bausen, Melanie
dc.contributor.author
Sprengel, Rolf
dc.contributor.author
Hasan, Mazahir T.
dc.date.accessioned
2018-06-08T04:08:06Z
dc.date.available
2015-05-07T07:34:09.180Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16649
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20830
dc.description.abstract
We have deployed recombinant adeno-associated viruses equipped with
tetracycline-controlled genetic switches to manipulate gene expression in
mouse brain. Here, we show a combinatorial genetic approach for inducible,
cell type-specific gene expression and Cre/loxP mediated gene recombination in
different brain regions. Our chemical-genetic approach will help to
investigate ‘when’, ‘where’, and ‘how’ gene(s) control neuronal circuit
dynamics, and organize, for example, sensory signal processing, learning and
memory, and behavior.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Inducible and combinatorial gene manipulation in mouse brain
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Front. Cell. Neurosci. - 9 (2015), Artikel Nr. 142
dcterms.bibliographicCitation.doi
10.3389/fncel.2015.00142
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3389/fncel.2015.00142
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022386
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004880
dcterms.accessRights.openaire
open access
