dc.contributor.author
Redy-Keisar, Orit
dc.contributor.author
Huth, Katharina
dc.contributor.author
Vogel, Uwe
dc.contributor.author
Lepenies, Bernd
dc.contributor.author
Seeberger, Peter H.
dc.contributor.author
Haag, Rainer
dc.contributor.author
Shabat, Doron
dc.date.accessioned
2018-06-08T04:03:19Z
dc.date.available
2016-09-27T11:43:06.891Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16492
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20673
dc.description.abstract
Near-infrared (NIR) fluorescent dyes are gaining increased attention due to
their potential to serve as molecular probes for in vivo imaging. Here, we
demonstrate that oligoglycerol dendrons effectively enhance the fluorescence
properties of an NIR dye by increasing the solubility in water and the
prevention of aggregate formation. First- and second-generation oligoglycerol
dendrons were conjugated to an NIR dye via a dipolar-cycloaddition (click)
reaction. The two new dye conjugates exhibited enhanced NIR fluorescent
emission and considerably higher fluorescent quantum yields than the dye
alone. The high photostability measured for one of the oligoglycerol-linked
dyes, in comparison to commonly used fluorogenic dyes such as Cy5 and Cy7, was
validated using fluorescence microscopy of macrophages.
en
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie
dc.title
Enhancement of fluorescent properties of near-infrared dyes using clickable
oligoglycerol dendrons
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Organic & Biomolecular Chemistry. - 13 (2015), 16, S. 4727-4732
dcterms.bibliographicCitation.doi
10.1039/C5OB00299K
dcterms.bibliographicCitation.url
http://pubs.rsc.org/en/content/articlelanding/2015/ob/c5ob00299k#!divAbstract
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000025427
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007125
dcterms.accessRights.openaire
open access