dc.contributor.author
Goldstein, Yaron A. B.
dc.contributor.author
Bockmayr, Alexander
dc.date.accessioned
2018-06-08T04:03:11Z
dc.date.available
2015-05-21T20:29:14.939Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16489
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20670
dc.description.abstract
Constraint-based modeling of genome-scale metabolic network reconstructions
has become a widely used approach in computational biology. Flux coupling
analysis is a constraint-based method that analyses the impact of single
reaction knockouts on other reactions in the network. We present an extension
of flux coupling analysis for double and multiple gene or reaction knockouts,
and develop corresponding algorithms for an in silico simulation. To evaluate
our method, we perform a full single and double knockout analysis on a
selection of genome-scale metabolic network reconstructions and compare the
results.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
constraint-based modeling
dc.subject
metabolic network
dc.subject
reaction knockout
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.title
Double and multiple knockout simulations for genome-scale metabolic network
reconstructions
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Algorithms for Molecular Biology (2015) 10:1
dcterms.bibliographicCitation.doi
10.1186/s13015-014-0028-y
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1186/s13015-014-0028-y
refubium.affiliation
Mathematik und Informatik
de
refubium.affiliation.other
Institut für Mathematik
refubium.funding
Deutsche Forschungsgemeinschaft (DFG)
refubium.mycore.fudocsId
FUDOCS_document_000000021961
refubium.note.author
Gefördert durch die DFG und den Open Access Publikationsfonds der Freien
Universität Berlin.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004608
dcterms.accessRights.openaire
open access
