dc.contributor.author
Meininger, Isabel
dc.contributor.author
Griesbach, Richard A.
dc.contributor.author
Hu, Desheng
dc.contributor.author
Gehring, Torben
dc.contributor.author
Seeholzer, Thomas
dc.contributor.author
Bertossi, Arianna
dc.contributor.author
Kranich, Jan
dc.contributor.author
Oeckinghaus, Andrea
dc.contributor.author
Eitelhuber, Andrea C.
dc.contributor.author
Greczmiel, Ute
dc.contributor.author
Gewies, Andreas
dc.contributor.author
Schmidt-Supprian, Marc
dc.contributor.author
Ruland, Juergen
dc.contributor.author
Brocker, Thomas
dc.contributor.author
Heissmeyer, Vigo
dc.contributor.author
Heyd, Florian
dc.contributor.author
Krappmann, Daniel
dc.date.accessioned
2018-06-08T03:58:47Z
dc.date.available
2016-05-12T10:34:57.418Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16334
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20517
dc.description.abstract
MALT1 channels proximal T-cell receptor (TCR) signalling to downstream
signalling pathways. With MALT1A and MALT1B two conserved splice variants
exist and we demonstrate here that MALT1 alternative splicing supports optimal
T-cell activation. Inclusion of exon7 in MALT1A facilitates the recruitment of
TRAF6, which augments MALT1 scaffolding function, but not protease activity.
Naive CD4+ T cells express almost exclusively MALT1B and MALT1A expression is
induced by TCR stimulation. We identify hnRNP U as a suppressor of exon7
inclusion. Whereas selective depletion of MALT1A impairs T-cell signalling and
activation, downregulation of hnRNP U enhances MALT1A expression and T-cell
activation. Thus, TCR-induced alternative splicing augments MALT1 scaffolding
to enhance downstream signalling and to promote optimal T-cell activation.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Biological sciences
dc.subject
Molecular biology
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::572 Biochemie
dc.title
Alternative splicing of MALT1 controls signalling and activation of CD4+ T
cells
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Nature Communications. - 7 (2016), Artikel Nr. 11292
dcterms.bibliographicCitation.doi
10.1038/ncomms11292
dcterms.bibliographicCitation.url
http://www.nature.com/ncomms/2016/160412/ncomms11292/full/ncomms11292.html
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000024508
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006389
dcterms.accessRights.openaire
open access