dc.contributor.author
Korting, H. C.
dc.contributor.author
Schöllmann, C.
dc.contributor.author
Stauss-Grabo, M.
dc.contributor.author
Schäfer-Korting, M.
dc.date.accessioned
2018-06-08T03:56:23Z
dc.date.available
2015-07-13T12:42:12.440Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16263
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20447
dc.description.abstract
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with
broad-spectrum microbicidal activity against both bacteria and fungi. In
mammals, AMPs form the first line of host defense against infections and
generally play an important role as effector agents of the innate immune
system. The AMP era was born more than 6 decades ago when the first cationic
cyclic peptide antibiotics, namely polymyxins and tyrothricin, found their way
into clinical use. Due to the good clinical experience in the treatment of,
for example, infections of mucus membranes as well as the subsequent
understanding of mode of action, AMPs are now considered for treatment of
inflammatory skin diseases and for improving healing of infected wounds. Based
on the preclinical findings, including pathobiochemistry and molecular
medicine, targeted therapy strategies are developed and first results indicate
that AMPs influence processes of diseased skin. Importantly, in contrast to
other antibiotics, AMPs do not seem to propagate the development of
antibiotic-resistant micro-organisms. Therefore, AMPs should be tested in
clinical trials for their efficacy and tolerability in inflammatory skin
diseases and chronic wounds. Apart from possible fields of application, these
peptides appear suited as an example of the paradigm of translational medicine
for skin diseases which is today seen as a ‘two-way road’ – from bench to
bedside and backwards from bedside to bench.
en
dc.rights.uri
http://www.karger.com/Journal/Guidelines/238704#15
dc.subject
Antimicrobial peptides
dc.subject
Translational medicine
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
Antimicrobial Peptides and Skin
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Skin Pharmacol Physiol. -25 (2012), 6, S. 323–334
dc.title.subtitle
A Paradigm of Translational Medicine
dcterms.bibliographicCitation.doi
10.1159/000341990
dcterms.bibliographicCitation.url
http://www.karger.com/Article/FullText/341990
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000022818
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005195
dcterms.accessRights.openaire
open access