dc.contributor.author
Almeida Ribeiro Jr., Euripides de
dc.contributor.author
Pinotsis, Nikos
dc.contributor.author
Ghisleni, Andrea
dc.contributor.author
Salmazo, Anita
dc.contributor.author
Konarev, Petr V.
dc.contributor.author
Kostan, Julius
dc.contributor.author
Sjöblom, Björn
dc.contributor.author
Schreiner, Claudia
dc.contributor.author
Polyansky, Anton A.
dc.contributor.author
Gkougkoulia, Eirini A.
dc.contributor.author
Holt, Mark R.
dc.contributor.author
Aachmann, Finn L.
dc.contributor.author
Žagrović, Bojan
dc.contributor.author
Bordignon, Enrica
dc.contributor.author
Pirker, Katharina F.
dc.contributor.author
Svergun, Dmitri I.
dc.contributor.author
Gautel, Mathias
dc.contributor.author
Djinović-Carugo, Kristina
dc.date.accessioned
2018-06-08T03:52:15Z
dc.date.available
2015-02-09T07:37:17.457Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16100
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20285
dc.description.abstract
The spectrin superfamily of proteins plays key roles in assembling the actin
cytoskeleton in various cell types, crosslinks actin filaments, and acts as
scaffolds for the assembly of large protein complexes involved in structural
integrity and mechanosensation, as well as cell signaling. α-actinins in
particular are the major actin crosslinkers in muscle Z-disks, focal
adhesions, and actin stress fibers. We report a complete high-resolution
structure of the 200 kDa α-actinin-2 dimer from striated muscle and explore
its functional implications on the biochemical and cellular level. The
structure provides insight into the phosphoinositide-based mechanism
controlling its interaction with sarcomeric proteins such as titin, lays a
foundation for studying the impact of pathogenic mutations at molecular
resolution, and is likely to be broadly relevant for the regulation of
spectrin-like proteins.
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.subject.ddc
500 Naturwissenschaften und Mathematik::530 Physik
dc.title
The Structure and Regulation of Human Muscle α-Actinin
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Cell. - 159 (2014), 6, S.1447-1460
dc.identifier.sepid
40705
dcterms.bibliographicCitation.doi
10.1016/j.cell.2014.10.056
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1016/j.cell.2014.10.056
refubium.affiliation
Physik
de
refubium.affiliation.other
Institut für Experimentalphysik
refubium.mycore.fudocsId
FUDOCS_document_000000021674
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004406
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
00928674