Title:
Generation of an iPS cell line from bone marrow derived mesenchymal stromal
cells from an elderly patient
Author(s):
Megges, Matthias; Geissler, Sven; Duda, Georg N.; Adjaye, James
Year of publication:
2015
Available Date:
2016-03-07T11:58:44.052Z
Abstract:
An induced pluripotent stem cell line was generated from primary human bone
marrow derived mesenchymal stromal cells of a 74 year old donor using
retroviruses harboring OCT4, SOX2, KLF4 and c-MYC in combination with the
following inhibitors TGFβ receptor-SB 431542, MEK-PD325901, and p53-Pifithrin
α. Pluripotency was confirmed both in vitro and in vivo.
DDC-Classification:
570 Biowissenschaften; Biologie
610 Medizin und Gesundheit
Publication Type:
Wissenschaftlicher Artikel
Also published in:
Stem Cell Research. - 15 (2015), 3, S. 565-568
URL of the Original Publication:
DOI of the Original Publication:
Department/institution:
Biologie, Chemie, Pharmazie
Charité - Universitätsmedizin Berlin
