dc.contributor.author
Awad, Wgeha A.
dc.contributor.author
Hess, Michael
dc.contributor.author
Twarużek, Magdalena
dc.contributor.author
Grajewski, Jan
dc.contributor.author
Kosicki, Robert
dc.contributor.author
Böhm, Jörgen
dc.contributor.author
Zentek, Jürgen
dc.date.accessioned
2018-06-08T03:41:47Z
dc.date.available
2013-01-31T15:16:36.964Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15740
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19927
dc.description.abstract
The aim of the present experiment was to investigate the effects of feeding
grains naturally contaminated with Fusarium mycotoxins on morphometric indices
of jejunum and to follow the passage of deoxynivalenol (DON) through
subsequent segments of the digestive tract of broilers. A total of 45 1-d-old
broiler chickens (Ross 308 males) were randomly allotted to three dietary
treatments (15 birds/treatment): (1) control diet; (2) diet contaminated with
1 mg DON/kg feed; (3) diet contaminated with 5 mg DON/kg feed for five weeks.
None of the zootechnical traits (body weight, body weight gain, feed intake,
and feed conversion) responded to increased DON levels in the diet. However,
DON at both dietary levels (1 mg and 5 mg DON/kg feed) significantly altered
the small intestinal morphology. In the jejunum, the villi were significantly
(P < 0.01) shorter in both DON treated groups compared with the controls.
Furthermore, the dietary inclusion of DON decreased (P < 0.05) the villus
surface area in both DON treated groups. The absolute or relative organ
weights (liver, heart, proventriculus, gizzard, small intestine, spleen,
pancreas, colon, cecum, bursa of Fabricius and thymus) were not altered (P >
0.05) in broilers fed the diet containing DON compared with controls. DON and
de-epoxy-DON (DOM-1) were analyzed in serum, bile, liver, feces and digesta
from consecutive segments of the digestive tract (gizzard, cecum, and rectum).
Concentrations of DON and its metabolite DOM-1 in serum, bile, and liver were
lower than the detection limits of the applied liquid chromatography coupled
with mass spectrometry (LC-MS/MS) method. Only about 10 to 12% and 6% of the
ingested DON was recovered in gizzard and feces, irrespective of the dietary
DON-concentration. However, the DON recovery in the cecum as percentage of
DON-intake varied between 18 to 22% and was not influenced by dietary DON-
concentration. Interestingly, in the present trial, DOM-1 did not appear in
the large intestine and in feces. The results indicate that deepoxydation in
the present study hardly occurred in the distal segments of the digestive
tract, assuming that the complete de-epoxydation occurs in the proximal small
intestine where the majority of the parent toxin is absorbed. In conclusion,
diets with DON contamination below levels that induce a negative impact on
performance could alter small intestinal morphology in broilers. Additionally,
the results confirm that the majority of the ingested DON quickly disappears
through the gastrointestinal tract.
de
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject
Fusarium mycotoxin
dc.subject
deoxynivalenol
dc.subject
small intestine
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::632 Schäden, Krankheiten, Schädlinge an Pflanzen
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::636 Viehwirtschaft
dc.title
The Impact of the Fusarium Mycotoxin Deoxynivalenol on the Health and
Performance of Broiler Chickens
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
International Journal of Molecular Sciences 12 (2011), S. 7996-8012
dcterms.bibliographicCitation.doi
10.3390/ijms12117996
dcterms.bibliographicCitation.url
http://doi.org/10.3390/ijms12117996
refubium.affiliation
Veterinärmedizin
de
refubium.mycore.fudocsId
FUDOCS_document_000000015919
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000002293
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1422-0067