Title:
Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport
of Hydrophobic Drugs
Author(s):
Walker, Karolina A.; Stumbe, Jean-Francois; Haag, Rainer
Year of publication:
2016
Available Date:
2016-07-15T12:02:00.002Z
Abstract:
A water-soluble, core-multishell (CMS) nanocarrier based on a new
hyperbranched polyester core building block was synthesized and characterized
towards drug transport and degradation of the nanocarrier. The hydrophobic
drug dexamethasone was encapsulated and the enzyme-mediated biodegradability
was investigated by NMR spectroscopy. The new CMS nanocarrier can transport
one molecule of dexamethasone and degrades within five days at a skin
temperature of 32 °C to biocompatible fragments.
Keywords:
nanocarrier
biodegradable
polyester
DDC-Classification:
540 Chemie
570 Biowissenschaften; Biologie
Publication Type:
Wissenschaftlicher Artikel
Also published in:
Polymers. - 8 (2016), 5, Artikel Nr. 192
URL of the Original Publication:
DOI of the Original Publication:
Department/institution:
Biologie, Chemie, Pharmazie
Comments:
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
