dc.contributor.author
Paßlack, Nadine
dc.contributor.author
Schmiedchen, Bettina
dc.contributor.author
Raila, Jens
dc.contributor.author
Schweigert, Florian J.
dc.contributor.author
Stumpff, Friederike
dc.contributor.author
Kohn, Barbara
dc.contributor.author
Neumann, Konrad
dc.contributor.author
Zentek, Jürgen
dc.date.accessioned
2018-06-08T03:32:01Z
dc.date.available
2016-05-04T12:59:44.901Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15386
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19574
dc.description.abstract
Background Dietary calcium (Ca) concentrations might affect regulatory
pathways within the Ca and vitamin D metabolism and consequently excretory
mechanisms. Considering large variations in Ca concentrations of feline diets,
the physiological impact on Ca homeostasis has not been evaluated to date. In
the present study, diets with increasing concentrations of dicalcium phosphate
were offered to ten healthy adult cats (Ca/phosphorus (P): 6.23/6.02,
7.77/7.56, 15.0/12.7, 19.0/17.3, 22.2/19.9, 24.3/21.6 g/kg dry matter). Each
feeding period was divided into a 10-day adaptation and an 8-day sampling
period in order to collect urine and faeces. On the last day of each feeding
period, blood samples were taken. Results Urinary Ca concentrations remained
unaffected, but faecal Ca concentrations increased (P < 0.001) with increasing
dietary Ca levels. No effect on whole and intact parathyroid hormone levels,
fibroblast growth factor 23 and calcitriol concentrations in the blood of the
cats were observed. However, the calcitriol precursors 25(OH)D2 and 25(OH)D3,
which are considered the most useful indicators for the vitamin D status,
decreased with higher dietary Ca levels (P = 0.013 and P = 0.033). Increasing
dietary levels of dicalcium phosphate revealed an acidifying effect on urinary
fasting pH (6.02) and postprandial pH (6.01) (P < 0.001), possibly mediated by
an increase of urinary phosphorus (P) concentrations (P < 0.001). Conclusions
In conclusion, calcitriol precursors were linearly affected by increasing
dietary Ca concentrations. The increase in faecal Ca excretion indicates that
Ca homeostasis of cats is mainly regulated in the intestine and not by the
kidneys. Long-term studies should investigate the physiological relevance of
the acidifying effect observed when feeding diets high in Ca and P.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
Impact of Increasing Dietary Calcium Levels on Calcium Excretion and Vitamin D
Metabolites in the Blood of Healthy Adult Cats
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLOS ONE. - 11 (2016), 2, Artikel Nr. e0149190
dc.identifier.sepid
48940
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0149190
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pone.0149190
refubium.affiliation
Veterinärmedizin
de
refubium.affiliation.other
Institut für Tierernährung
refubium.funding
Deutsche Forschungsgemeinschaft (DFG)
refubium.funding.id
1346
refubium.mycore.fudocsId
FUDOCS_document_000000024018
refubium.note.author
Gefördert durch die DFG und den Open-Access-Publikationsfonds der Freien
Universität Berlin.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006025
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1932-6203