dc.contributor.author
Van, Dana Vu
dc.contributor.author
Beier, Katja C.
dc.contributor.author
Pietzke, Lea-Jean
dc.contributor.author
Baz, Maysun S. Al
dc.contributor.author
Feist, Randi K.
dc.contributor.author
Gurka, Stephanie
dc.contributor.author
Hamelmann, Eckard
dc.contributor.author
Kroczek, Richard A.
dc.contributor.author
Hutloff, Andreas
dc.date.accessioned
2018-06-08T03:31:48Z
dc.date.available
2016-04-04T11:49:16.103Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15379
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19567
dc.description.abstract
Autoimmune diseases and other inflammatory conditions are characterized by
large lymphocytic tissue infiltrates in which T and B cells can be found in
close contact. Here, using a murine airway inflammation model, we compare
antigen-specific T and B cells in lung tissue versus lung-draining lymph node.
In the lung we identify a B-cell population exhibiting a classical germinal
centre phenotype without being organized into ectopic lymphoid tissue. By
contrast, classical CXCR5+ Bcl-6+ T follicular helper cells are not present.
Nevertheless, lung-infiltrating T cells exhibit follicular helper-like
properties including the potential to provide help to naive B cells. The lung
tissue is also a survival niche for memory T and B cells remaining in residual
peribronchial infiltrates after resolution of inflammation. Collectively, this
study shows the importance of T/B cooperation not only in lymph nodes but also
in inflamed peripheral tissues for local antibody responses to infection and
autoimmunity.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Biological sciences
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.title
Local T/B cooperation in inflamed tissues is supported by T follicular helper-
like cells
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Nature Communications. - 7 (2016), Artikel Nr. 10875
dcterms.bibliographicCitation.doi
10.1038/ncomms10875
dcterms.bibliographicCitation.url
http://www.nature.com/ncomms/2016/160226/ncomms10875/full/ncomms10875.html
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024322
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006235
dcterms.accessRights.openaire
open access