dc.contributor.author
Winter, Lukas
dc.contributor.author
Oezerdem, Celal
dc.contributor.author
Hoffmann, Werner
dc.contributor.author
Lindt, Tessa van de
dc.contributor.author
Periquito, Joao
dc.contributor.author
Ghadjar, Pirus
dc.contributor.author
Budach, Volker
dc.contributor.author
Wust, Peter
dc.contributor.author
Niendorf, Thoralf
dc.date.accessioned
2018-06-08T03:28:38Z
dc.date.available
2015-10-12T08:02:52.182Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15268
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19456
dc.description.abstract
Background Glioblastoma multiforme is the most common and most aggressive
malign brain tumor. The 5-year survival rate after tumor resection and
adjuvant chemoradiation is only 10 %, with almost all recurrences occurring in
the initially treated site. Attempts to improve local control using a higher
radiation dose were not successful so that alternative additive treatments are
urgently needed. Given the strong rationale for hyperthermia as part of a
multimodal treatment for patients with glioblastoma, non-invasive radio
frequency (RF) hyperthermia might significantly improve treatment results.
Methods A non-invasive applicator was constructed utilizing the magnetic
resonance (MR) spin excitation frequency for controlled RF hyperthermia and MR
imaging in an integrated system, which we refer to as thermal MR. Applicator
designs at RF frequencies 300 MHz, 500 MHz and 1GHz were investigated and
examined for absolute applicable thermal dose and temperature hotspot size.
Electromagnetic field (EMF) and temperature simulations were performed in
human voxel models. RF heating experiments were conducted at 300 MHz and 500
MHz to characterize the applicator performance and validate the simulations.
Results The feasibility of thermal MR was demonstrated at 7.0 T. The
temperature could be increased by ~11 °C in 3 min in the center of a head
sized phantom. Modification of the RF phases allowed steering of a temperature
hotspot to a deliberately selected location. RF heating was monitored using
the integrated system for MR thermometry and high spatial resolution MRI. EMF
and thermal simulations demonstrated that local RF hyperthermia using the
integrated system is feasible to reach a maximum temperature in the center of
the human brain of 46.8 °C after 3 min of RF heating while surface
temperatures stayed below 41 °C. Using higher RF frequencies reduces the size
of the temperature hotspot significantly. Conclusion The opportunities and
capabilities of thermal magnetic resonance for RF hyperthermia interventions
of intracranial lesions are intriguing. Employing such systems as an
alternative additive treatment for glioblastoma multiforme might be able to
improve local control by “fighting fire with fire”. Interventions are not
limited to the human brain and might include temperature driven targeted drug
and MR contrast agent delivery and help to understand temperature dependent
bio- and physiological processes in-vivo.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Thermal magnetic resonance
dc.subject
Magnetic resonance imaging
dc.subject
Radio frequency
dc.subject
RF coil technology
dc.subject
Gliablastoma multiforme
dc.subject
Radiation oncology
dc.subject
Targeted drug delivery
dc.subject
Thermal therapies
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::600 Technik::600 Technik, Technologie
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Thermal magnetic resonance
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Radiation Oncology. - 10 (2015), 1, Artikel Nr. 201
dc.title.subtitle
physics considerations and electromagnetic field simulations up to 23.5 Tesla
(1GHz)
dcterms.bibliographicCitation.doi
10.1186/s13014-015-0510-9
dcterms.bibliographicCitation.url
http://www.ro-journal.com/content/10/1/201
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000023277
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publizert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005517
dcterms.accessRights.openaire
open access