dc.contributor.author
Arsenic, Ruza
dc.contributor.author
Braicu, Elena Ilona
dc.contributor.author
Letsch, Anne
dc.contributor.author
Dietel, Manfred
dc.contributor.author
Sehouli, Jalid
dc.contributor.author
Keilholz, Ulrich
dc.contributor.author
Ochsenreither, Sebastian
dc.date.accessioned
2018-06-08T03:28:32Z
dc.date.available
2015-11-16T12:48:16.645Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15265
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19453
dc.description.abstract
Background Cyclin A1 is essential for male gametopoiesis. In acute myeloid
leukemia, it acts as a leukemia-associated antigen. Cyclin A1 expression has
been reported in several epithelial malignancies, including testicular,
endometrial, and epithelial ovarian cancer (EOC). We analyzed Cyclin A1
expression in EOC and its correlation with clinical features to evaluate
Cyclin A1 as a T-cell target in EOC. Methods Cyclin A1 mRNA expression in EOC
and healthy tissues was quantified by microarray analysis and quantitative
real-time PCR (qRT-PCR). Protein expression in clinical samples was assessed
by immunohistochemistry (IHC) and was correlated to clinical features. Results
Cyclin A1 protein was homogeneously expressed in 43 of 62 grade 3 tumor
samples and in 1 of 10 grade 2 specimens (p < 0.001). Survival analysis showed
longer time to progression (TTP) among patients with at least moderate Cyclin
A1 expression (univariate: p = 0.018, multivariate: p = 0.035). FIGO stage,
grading, age, macroscopic residual tumor after debulking, and peritoneal
carcinomatosis / distant metastasis had no impact on TTP or overall survival
(OS). Conclusion Cyclin A1 is highly expressed in most EOCs. The mechanism
behind the prolonged TTP in patients with high Cyclin A1 expression warrants
further investigation. The frequent, selectively high expression of Cyclin A1
in EOC makes it a promising target for T-cell therapies.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Ovarian cancer
dc.subject
Cytotoxic T-lymphocytes
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Cancer-testis antigen cyclin A1 is broadly expressed in ovarian cancer and is
associated with prolonged time to tumor progression after platinum-based
therapy
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
BMC Cancer. - 15 (2015), Artikel Nr. 784
dcterms.bibliographicCitation.doi
10.1186/s12885-015-1824-6
dcterms.bibliographicCitation.url
http://www.biomedcentral.com/1471-2407/15/784
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000023468
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005662
dcterms.accessRights.openaire
open access