dc.contributor.author
Parr, M. K.
dc.contributor.author
Botrè, F.
dc.contributor.author
Naß, A.
dc.contributor.author
Hengevoss, J.
dc.contributor.author
Diel, P.
dc.contributor.author
Wolber, G.
dc.date.accessioned
2018-06-08T03:21:29Z
dc.date.available
2015-07-29T08:51:56.491Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14998
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19186
dc.description.abstract
Increasing numbers of dietary supplements with ecdysteroids are marketed as
“natural anabolic agents”. Results of recent studies suggested that their
anabolic effect is mediated by estrogen receptor (ER) binding. Within this
study the anabolic potency of ecdysterone was compared to well characterized
anabolic substances. Effects on the fiber sizes of the soleus muscle in rats
as well the diameter of C2C12 derived myotubes were used as biological
readouts. Ecdysterone exhibited a strong hypertrophic effect on the fiber size
of rat soleus muscle that was found even stronger compared to the test
compounds metandienone (dianabol), estradienedione (trenbolox), and SARM S 1,
all administered in the same dose (5 mg/kg body weight, for 21 days). In C2C12
myotubes ecdysterone (1 µM) induced a significant increase of the diameter
comparable to dihydrotestosterone (1 µM) and IGF 1 (1.3 nM). Molecular docking
experiments supported the ERβ mediated action of ecdysterone. To clarify its
status in sports, ecdysterone should be considered to be included in the class
“S1.2 Other Anabolic Agents” of the list of prohibited substances of the World
Anti-Doping Agency.
de
dc.rights.uri
http://biolsport.com/text.php?ids=1111
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Biology of sport. - 32 (2015), 2, S. 169-173
dc.title.subtitle
A novel class of anabolic agents?
dcterms.bibliographicCitation.doi
10.5604/20831862.1144420
dcterms.bibliographicCitation.url
http://183.indexcopernicus.com/abstracted.php?level=5&ICID=1144420
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000022895
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005257
dcterms.accessRights.openaire
open access