dc.contributor.author
Vonberg, Isabelle
dc.contributor.author
Ehlen, Felicitas
dc.contributor.author
Fromm, Ortwin
dc.contributor.author
Kühn, Andrea A.
dc.contributor.author
Klostermann, Fabian
dc.date.accessioned
2018-06-08T03:15:23Z
dc.date.available
2016-10-18T08:43:12.702Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14792
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18981
dc.description.abstract
Objective Reduced verbal fluency (VF) has been reported in patients with
Parkinson’s disease (PD), especially those treated by Deep Brain Stimulation
of the subthalamic nucleus (STN DBS). To delineate the nature of this
dysfunction we aimed at identifying the particular VF-related operations
modified by STN DBS. Method Eleven PD patients performed VF tasks in their STN
DBS ON and OFF condition. To differentiate VF-components modulated by the
stimulation, a temporal cluster analysis was performed, separating production
spurts (i.e., ‘clusters’ as correlates of automatic activation spread within
lexical fields) from slower cluster transitions (i.e., ‘switches’ reflecting
set-shifting towards new lexical fields). The results were compared to those
of eleven healthy control subjects. Results PD patients produced significantly
more switches accompanied by shorter switch times in the STN DBS ON compared
to the STN DBS OFF condition. The number of clusters and time intervals
between words within clusters were not affected by the treatment state.
Although switch behavior in patients with DBS ON improved, their task
performance was still lower compared to that of healthy controls. Discussion
Beyond impacting on motor symptoms, STN DBS seems to influence the dynamics of
cognitive procedures. Specifically, the results are in line with basal ganglia
roles for cognitive switching, in the particular case of VF, from prevailing
lexical concepts to new ones.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching
in Parkinsons Disease Patients
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 11 (2016), 8, Artikel Nr. e0161404
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0161404
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pone.0161404
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000025558
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007221
dcterms.accessRights.openaire
open access