dc.contributor.author
Laginha, Ines
dc.contributor.author
Kopp, Marcel A.
dc.contributor.author
Druschel, Claudia
dc.contributor.author
Schaser, Klaus-Dieter
dc.contributor.author
Brommer, Benedikt
dc.contributor.author
Hellmann, Rick C.
dc.contributor.author
Watzlawick, Ralf
dc.contributor.author
Ossami-Saidi, Ramin-Raul
dc.contributor.author
Pruess, Harald
dc.contributor.author
Failli, Vieri
dc.contributor.author
Meisel, Christian
dc.contributor.author
Liebscher, Thomas
dc.contributor.author
Prilipp, Erik
dc.contributor.author
Niedeggen, Andreas
dc.contributor.author
Ekkernkamp, Axel
dc.contributor.author
Grittner, Ulrike
dc.contributor.author
Piper, Sophie K.
dc.contributor.author
Dirnagl, Ulrich
dc.contributor.author
Killig, Monica
dc.contributor.author
Romagnani, Chiara
dc.contributor.author
Schwab, Jan M.
dc.date.accessioned
2018-06-08T03:14:36Z
dc.date.available
2016-11-03T12:24:37.236Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14768
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18958
dc.description.abstract
Background Natural killer (NK) cells comprise the main components of
lymphocyte-mediated nonspecific immunity. Through their effector function they
play a crucial role combating bacterial and viral challenges. They are also
thought to be key contributors to the systemic spinal cord injury-induced
immune-deficiency syndrome (SCI-IDS). SCI-IDS increases susceptibility to
infection and extends to the post-acute and chronic phases after SCI. Methods
and design The prospective study of NK cell function after traumatic SCI was
carried out in two centers in Berlin, Germany. SCI patients and control
patients with neurologically silent vertebral fracture also undergoing
surgical stabilization were enrolled. Furthermore healthy controls were
included to provide reference data. The NK cell function was assessed at 7
(5–9) days, 14 days (11–28) days, and 10 (8–12) weeks post-trauma. Clinical
documentation included the American Spinal Injury Association (ASIA)
impairment scale (AIS), neurological level of injury, infection status,
concomitant injury, and medications. The primary endpoint of the study is
CD107a expression by NK cells (cytotoxicity marker) 8–12 weeks following SCI.
Secondary endpoints are the NK cell’s TNF-α and IFN-γ production by the NK
cells 8–12 weeks following SCI. Discussion The protocol of this study was
developed to investigate the hypotheses whether i) SCI impairs NK cell
function throughout the post-acute and sub-acute phases after SCI and ii) the
degree of impairment relates to lesion height and severity. A deeper
understanding of the SCI-IDS is crucial to enable strategies for prevention of
infections, which are associated with poor neurological outcome and elevated
mortality. Trial registration DRKS00009855.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Spinal cord injury
dc.subject
NK cells function
dc.subject
Immune paralysis
dc.subject
Lesion height dependency
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Natural Killer (NK) Cell Functionality after human Spinal Cord Injury (SCI)
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
BMC Neurology. - 16 (2016), Artikel Nr. 170
dc.title.subtitle
protocol of a prospective, longitudinal study
dcterms.bibliographicCitation.doi
10.1186/s12883-016-0681-
dcterms.bibliographicCitation.url
http://bmcneurol.biomedcentral.com/articles/10.1186/s12883-016-0681-5
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000025657
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007303
dcterms.accessRights.openaire
open access