dc.contributor.author
Rentzsch, Johannes
dc.contributor.author
Shen, Christina
dc.contributor.author
Jockers-Scherübl, Maria C.
dc.contributor.author
Gallinat, Jürgen
dc.contributor.author
Neuhaus, Andres H.
dc.date.accessioned
2018-06-08T03:13:55Z
dc.date.available
2015-07-28T11:06:34.249Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14741
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18931
dc.description.abstract
Background The predictive coding model is rapidly gaining attention in
schizophrenia research. It posits the neuronal computation of residual
variance (‘prediction error’) between sensory information and top-down
expectation through multiple hierarchical levels. Event-related potentials
(ERP) reflect cortical processing stages that are increasingly interpreted in
the light of the predictive coding hypothesis. Both mismatch negativity (MMN)
and repetition suppression (RS) measures are considered a prediction error
correlates based on error detection and error minimization, respectively.
Methods Twenty-five schizophrenia patients and 25 healthy controls completed
auditory tasks designed to elicit MMN and RS responses that were investigated
using repeated measures models and strong spatio-temporal a priori hypothesis
based on previous research. Separate correlations were performed for controls
and schizophrenia patients, using age and clinical variables as covariates.
Results MMN and RS deficits were largely replicated in our sample of
schizophrenia patients. Moreover, MMN and RS measures were strongly correlated
in healthy controls, while no correlation was found in schizophrenia patients.
Single-trial analyses indicated significantly lower signal-to-noise ratio
during prediction error computation in schizophrenia. Conclusions This study
provides evidence that auditory ERP components relevant for schizophrenia
research can be reconciled in the light of the predictive coding framework.
The lack of any correlation between the investigated measures in schizophrenia
patients suggests a disruption of predictive coding mechanisms in general.
More specifically, these results suggest that schizophrenia is associated with
an irregular computation of residual variance between sensory input and top-
down models, i.e. prediction error.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Auditory Mismatch Negativity and Repetition Suppression Deficits in
Schizophrenia Explained by Irregular Computation of Prediction Error
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 10 (2015), 5, Artikel Nr. e0126775
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0126775
dcterms.bibliographicCitation.url
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126775
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022892
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005254
dcterms.accessRights.openaire
open access