Title:
Modular automated solid phase synthesis of dermatan sulfate oligosaccharides
Author(s):
Kandasamy, Jeyakumar; Schuhmacher, Frank; Hahm, Heung Sik; Klein, James C.; Seeberger, Peter H.
Year of publication:
2014
Available Date:
2016-09-28T11:23:26.438Z
Abstract:
Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude
of biological roles as part of the extracellular matrix. Orthogonally
protected D-galactosamine and L-iduronic acid building blocks and a photo-
cleavable linker are instrumental for the automated synthesis of dermatan
sulfate oligosaccharides. Conjugation-ready oligosaccharides were obtained in
good yield.
DDC-Classification:
540 Chemie
Publication Type:
Wissenschaftlicher Artikel
Also published in:
Chemical Communications. - 50 (2014), 15, S. 1875-1877
URL of the Original Publication:
DOI of the Original Publication:
Department/institution:
Biologie, Chemie, Pharmazie
