dc.contributor.author
Hamann, Lutz
dc.contributor.author
Kupcinskas, Juozas
dc.contributor.author
Almanza, Luis C. Berrocal
dc.contributor.author
Skieceviciene, Jurgita
dc.contributor.author
Franke, Andre
dc.contributor.author
Nöthlings, Ute
dc.contributor.author
Schumann, Ralf R.
dc.date.accessioned
2018-06-08T03:06:54Z
dc.date.available
2015-08-25T07:41:50.333Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14537
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18729
dc.description.abstract
Background Determining the prerequisites for healthy aging is a major task in
the modern world characterized by a longer lifespan of the individuals.
Besides lifestyle and environmental influences genetic factors are involved as
shown by several genome-wide association studies. Older individuals are known
to have an impaired immune response, a condition recently termed “inflamm-
aging”. We hypothesize that the induction of this condition in the elderly is
influenced by the sensitivity of the innate immune system. Therefore, we
investigated genetic variants of the Toll-like receptor (TLR) family, one of
the major family of innate immune receptors, for association with age in two
cohorts of healthy, disease-free subjects. Results According to sex we found a
positive association of loss-of-function variants of TLR-1 and −6 with healthy
aging with odds ratios of 1.54 in males for TLR-6 (249 S/S), and 1.41, 1.66,
and 1.64 in females for TLR-1 prom., TLR-1 (248 S/S), and TLR-1 (602 S/S),
respectively. Thus, the presence of these variants increases the probability
of achieving healthy old age and indicates that a reduced TLR activity may be
beneficial in the elderly. Conclusions This is the first report showing an
association of TLR variants with age. While a loss of function of an important
immune receptor may be a risk factor for acute infections as has been shown
previously, in the setting of healthy ageing it appears to be protective,
which may relate to “inflamm-aging”. These first results should be reproduced
in larger trials to confirm this hypothesis.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Innate immunity
dc.subject
Toll-like receptors
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Less functional variants of TLR-1/-6/-10 genes are associated with age
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Immunity & Ageing. - 12 (2015), 1, Art Nr. 7
dcterms.bibliographicCitation.doi
10.1186/s12979-015-0034-z
dcterms.bibliographicCitation.url
http://www.immunityageing.com/content/12/1/7
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022965
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005303
dcterms.accessRights.openaire
open access