dc.contributor.author
Caspari, Franziska
dc.contributor.author
Baumann, Veronika J.
dc.contributor.author
Garcia-Pino, Elisabet
dc.contributor.author
Koch, Ursula
dc.date.accessioned
2018-06-08T02:59:29Z
dc.date.available
2016-01-13T14:56:31.651Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14277
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18472
dc.description.abstract
The ventral nucleus of the lateral lemniscus (VNLL) provides a major
inhibitory projection to the inferior colliculus (IC). Neurons in the VNLL
respond with various firing patterns and different temporal precision to
acoustic stimulation. The present study investigates the underlying intrinsic
and synaptic properties of various cell types in different regions of the
VNLL, using in vitro electrophysiological recordings from acute brain slices
of mice and immunohistochemistry. We show that the biophysical membrane
properties and excitatory input characteristics differed between dorsal and
ventral VNLL neurons. Neurons in the ventral VNLL displayed an onset-type
firing pattern and little hyperpolarization-activated current (Ih).
Stimulation of lemniscal inputs evoked a large all-or-none excitatory response
similar to Calyx of Held synapses in neurons in the lateral part of the
ventral VNLL. Neurons that were located within the fiber tract of the lateral
lemniscus, received several and weak excitatory input fibers. In the dorsal
VNLL onset-type and sustained firing neurons were intermingled. These neurons
showed large Ih and were strongly immunopositive for the hyperpolarization-
activated cyclic nucleotide-gated channel 1 (HCN1) subunit. Both neuron types
received several excitatory inputs that were weaker and slower compared to
ventrolateral VNLL neurons. Using a mouse model that expresses
channelrhodopsin under the promotor of the vesicular GABA transporter (VGAT)
suggests that dorsal and ventral neurons were inhibitory since they were all
depolarized by light stimulation. The diverse membrane and input properties in
dorsal and ventral VNLL neurons suggest differential roles of these neurons
for sound processing.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
auditory brainstem
dc.subject
membrane properties
dc.subject
synaptic transmission
dc.subject
hyperpolarization-activated current
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.title
Heterogeneity of Intrinsic and Synaptic Properties of Neurons in the Ventral
and Dorsal Parts of the Ventral Nucleus of the Lateral Lemniscus
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Front. Neural Circuits. - 9 (2015), Artikel Nr. 74
dcterms.bibliographicCitation.doi
10.3389/fncir.2015.00074
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3389/fncir.2015.00074
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000023615
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005775
dcterms.accessRights.openaire
open access