dc.contributor.author
Potsika, Vassiliki T.
dc.contributor.author
Grivas, Konstantinos N.
dc.contributor.author
Gortsas, Theodoros
dc.contributor.author
Iori, Gianluca
dc.contributor.author
Protopappas, Vasilios C.
dc.contributor.author
Raum, Kay
dc.contributor.author
Polyzos, Demosthenes
dc.contributor.author
Fotiadis, Dimitrios I.
dc.date.accessioned
2018-06-08T02:58:31Z
dc.date.available
2016-05-18T10:26:40.089Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14242
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18437
dc.description.abstract
Computational studies on the evaluation of bone status in cases of pathologies
have gained significant interest in recent years. This work presents a
parametric and systematic numerical study on ultrasound propagation in
cortical bone models to investigate the effect of changes in cortical porosity
and the occurrence of large basic multicellular units, simply called non-
refilled resorption lacunae (RL), on the velocity of the first arriving signal
(FAS). Two-dimensional geometries of cortical bone are established for various
microstructural models mimicking normal and pathological tissue states.
Emphasis is given on the detection of RL formation which may provoke the
thinning of the cortical cortex and the increase of porosity at a later stage
of the disease. The central excitation frequencies 0.5 and 1 MHz are examined.
The proposed configuration consists of one point source and multiple
successive receivers in order to calculate the FAS velocity in small
propagation paths (local velocity) and derive a variation profile along the
cortical surface. It was shown that: (a) the local FAS velocity can capture
porosity changes including the occurrence of RL with different number, size
and depth of formation; and (b) the excitation frequency 0.5 MHz is more
sensitive for the assessment of cortical microstructure.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
cortical porosity
dc.subject
basic multicellular units
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Computational Study of the Effect of Cortical Porosity on Ultrasound Wave
Propagation in Healthy and Osteoporotic Long Bones
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Materials. - 9 (2016), 3, Artikel Nr. 205
dcterms.bibliographicCitation.doi
10.3390/ma9030205
dcterms.bibliographicCitation.url
http://www.mdpi.com/1996-1944/9/3/205
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024566
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006431
dcterms.accessRights.openaire
open access