dc.contributor.author
Mobascher, A.
dc.contributor.author
Diaz-Lacava, A.
dc.contributor.author
Wagner, M.
dc.contributor.author
Gallinat, J.
dc.contributor.author
Wienker, T. F.
dc.contributor.author
Drichel, D.
dc.contributor.author
Becker, T.
dc.contributor.author
Steffens, M.
dc.contributor.author
Dahmen, N.
dc.contributor.author
Gründer, G.
dc.contributor.author
Thürauf, N.
dc.contributor.author
Kiefer, F.
dc.contributor.author
Kornhuber, J.
dc.contributor.author
Toliat, M. R.
dc.contributor.author
Thiele, H.
dc.contributor.author
Nürnberg, P.
dc.contributor.author
Steinlein, O.
dc.contributor.author
Winterer, G.
dc.date.accessioned
2018-06-08T02:58:04Z
dc.date.available
2016-05-09T11:29:27.788Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/14218
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-18414
dc.description.abstract
Variation in genes coding for nicotinic acetylcholine receptor (nAChR)
subunits affect cognitive processes and may contribute to the genetic
architecture of neuropsychiatric disorders. Single nucleotide polymorphisms
(SNPs) in the CHRNA4 gene that codes for the alpha4 subunit of
alpha4/beta2-containing receptors have previously been implicated in aspects
of (mostly visual) attention and smoking-related behavioral measures. Here we
investigated the effects of six synonymous but functional CHRNA4 exon 5 SNPs
on the N100 event-related potential (ERP), an electrophysiological
endophenotype elicited by a standard auditory oddball. A total of N = 1,705
subjects randomly selected from the general population were studied with
electroencephalography (EEG) as part of the German Multicenter Study on
nicotine addiction. Two of the six variants, rs1044396 and neighboring
rs1044397, were significantly associated with N100 amplitude. This effect was
pronounced in females where we also observed an effect on reaction time.
Sequencing of the complete exon 5 region in the population sample excluded the
existence of additional/functional variants that may be responsible for the
observed effects. This is the first large-scale population-based study
investigation the effects of CHRNA4 SNPs on brain activity measures related to
stimulus processing and attention. Our results provide further evidence that
common synonymous CHRNA4 exon 5 SNPs affect cognitive processes and suggest
that they also play a role in the auditory system. As N100 amplitude reduction
is considered a schizophrenia-related endophenotype the SNPs studied here may
also be associated with schizophrenia outcome measures.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor
Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large
Population-Based Sample
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 11 (2016), 4, Artikel Nr. e0152984
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0152984
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pone.0152984
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024487
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006376
dcterms.accessRights.openaire
open access