Haupttitel:
Characterization of Anticancer Drug Protomers Using Electrospray Ionization and Ion Mobility Spectrometry–Mass Spectrometry
Autor*in:
Basuri, Pallab; Safferthal, Marc; Kovacevic, Borislav; Schorr, Pascal; Riedel, Jerome; Pagel, Kevin; Volmer, Dietrich A.
Datum der Freigabe:
2024-12-10T06:37:16Z
Abstract:
We used electrospray ionization and ion mobility spectrometry–mass spectrometry to detect and characterize the three anticancer drugs palbociclib, copanlisib, and olaparib. Ion mobility–mass spectrometry and density functional theory revealed that these compounds generate isomers during ionization (protomers) due to the presence of multiple protonation sites within their chemical structures. Our work has implications for understanding the solution- and gas-phase chemistry of these molecules during spray-based ionization processes.
Teil des Identifiers:
e-ISSN (online): 1879-1123
Freie Schlagwörter:
Gases
Ionization
Ions
Molecules
Reaction mechanisms
DDC-Klassifikation:
540 Chemie und zugeordnete Wissenschaften
Publikationstyp:
Wissenschaftlicher Artikel
Zeitschrift:
Journal of the American Society for Mass Spectrometry
Fachbereich/Einrichtung:
Biologie, Chemie, Pharmazie
Institut für Chemie und Biochemie