Title:
Intersexual Twins due to Tetragametic Chimerism
Author(s):
Wimmer, Rainer; Neumann, Uta; Weber, André; Isau, Melanie; Renner-Luetzkendorf, Heike; Zschieschang, Petra; Wachter, Oliver; Hirv, Kaimo; Stumm, Markus
Year of publication:
2022
Available Date:
2024-09-24T13:44:41Z
Abstract:
Disorders of or differences in sexual development (DSD) are defined by congenital conditions in which development of chromosomal, gonadal, or anatomic sex are atypical. Here, we report on monochorionic diamniotic twins delivered by Caesarean section in the 36th week of pregnancy. Monochorionic twins are usually monozygous and thus should have the same sexual differentiation. In this case, one twin had female external genitalia, while the other showed ambiguous genitalia. At first, a diagnosis of mixed gonadal dysgenesis was proposed because of the obvious sexual discrepancy between the supposedly monozygous twins. Cytogenetic analyses were performed to assure the sex chromosome status for both children. Male and female cells were found subsequently in both children. While hematopoietic chimerism of monochorionic dizygous twins as a result of twin-to-twin blood transfusion is a rare but already well documented phenomenon, to our knowledge this is the first case description of tetragametic chimerism that led to intersexuality.
Part of Identifier:
ISSN (print): 1424-8581
e-ISSN (online): 1424-859X
Keywords:
cesarean section
child
chimerism
chimerism
DDC-Classification:
610 Medizin und Gesundheit
Publication Type:
Wissenschaftlicher Artikel
DOI of the Original Publication:
PubMed ID of the Original Publication:
Journaltitle:
Cytogenetic and Genome Research
Copyright Publisher:
Copyright applies in this work.
Department/institution:
Charité - Universitätsmedizin Berlin
Comments:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
This publication is shared with permission of the rights owner and made freely accessible through a DFG (German Research Foundation) funded license at either an alliance or national level.