Western Europe’s agrifood systems are highly developed, extremely complex, and dependably produce food for billions. Securing their functionality is imperative whilst dealing with varieties of major challenges and opportunities in the future. Multiple stakeholders are involved in system transitions; therefore, synthesizing views from different scientific disciplines is essential for a robust trend analysis. Through workshops with a variety of experts, extensive research, followed by close monitoring over 5 years, we identified trends that will influence the shape of the evolving agrifood systems. Based on this, we determined which trends need addressing by agrifood research to secure the system’s future functioning. We detected nine trends with 50 sub-topics that will shape the future of Western European agrifood systems, of which 5 are classified as macro- and 4 as micro-trends. Our second objective was to improve the efforts of the stakeholders in- and outside of the agrifood area to secure functioning and further improvement through giving a comprehensive overview. This contributes to enhanced strategies for sustainable and resilient agrifood systems that produce sufficient affordable nutritious food for a planetary health diet, and hence, supporting successful implementation of selected goals from the 2030 Agenda for Sustainable Development and the European Green Deal.