Title:
One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors
Author(s):
Ahmadi, Vahid; Nie, Chuanxiong; Mohammadifar, Ehsan; Achazi, Katharina; Wedepohl, Stefanie; Kerkhoff, Yannic; Block, Stephan; Osterrieder, Klaus; Haag, Rainer
Year of publication:
2021
Available Date:
2021-11-30T09:07:31Z
Abstract:
A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.
Part of Identifier:
e-ISSN (online): 1364-548X
Keywords:
herpes simplex virus type 1
virustatic inhibition
gram-scale synthesis
DDC-Classification:
540 Chemie und zugeordnete Wissenschaften
Publication Type:
Wissenschaftlicher Artikel
URL of the Original Publication:
DOI of the Original Publication:
Journaltitle:
Chemical Communications
Department/institution:
Biologie, Chemie, Pharmazie
Veterinärmedizin
Institut für Chemie und Biochemie
Institut für Virologie