id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.pmid,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eissn,refubium.affiliation,refubium.funding,refubium.resourceType.isindependentpub "23478ae2-8bc8-4a73-ba8f-929276754835","fub188/15","Gaubert, Malo||Lange, Catharina||Garnier-Crussard, Antoine||Köbe, Theresa||Bougacha, Salma||Gonneaud, Julie||de Flores, Robin||Tomadesso, Clémence||Mézenge, Florence||Landeau, Brigitte||de la Sayette, Vincent||Chételat, Gaël||Wirth, Miranka","2023-03-17T15:48:34Z","2023-03-17T15:48:34Z","2021","Background: White matter hyperintensities (WMH) are frequently found in Alzheimer's disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (A beta) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH associated with A beta burden, glucose hypometabolism, and gray matter volume reduction. Methods: In a total of 155 participants (IMAP+ cohort) across the cognitive continuum from normal cognition to AD dementia, FLAIR MRI, AV45-PET, FDG-PET, and T1 MRI were acquired. WMH were automatically segmented from FLAIR images. Mean levels of neocortical A beta deposition (AV45-PET), temporo-parietal glucose metabolism (FDG-PET), and medial-temporal gray matter volume (GMV) were extracted from processed images using established AD meta-signature templates. Associations between AD brain biomarkers and WMH, as assessed in region-of-interest and voxel-wise, were examined, adjusting for age, sex, education, and systolic blood pressure. Results: There were no significant associations between global A beta burden and region-specific WMH. Voxel-wise WMH in the splenium of the corpus callosum correlated with greater A beta deposition at a more liberal threshold. Region- and voxel-based WMH in the posterior corpus callosum, along with parietal, occipital, and frontal areas, were associated with lower temporo-parietal glucose metabolism. Similarly, lower medial-temporal GMV correlated with WMH in the posterior corpus callosum in addition to parietal, occipital, and fontal areas. Conclusions: This study demonstrates that local white matter damage is correlated with multimodal brain biomarkers of AD. Our results highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter. Overall, these cross-sectional findings corroborate associations of regional WMH with AD-typical Ass deposition and neurodegeneration.","https://refubium.fu-berlin.de/handle/fub188/38454||http://dx.doi.org/10.17169/refubium-38172","eng","https://creativecommons.org/licenses/by/4.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","Cerebrovascular disease||Alzheimer's disease||Alzheimer's disease pathology||White matter lesion","Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease","Wissenschaftlicher Artikel","open access","29","10.1186/s13195-020-00759-3","Alzheimer's Research & Therapy","Springer Nature","33461618","13","1758-9193","Charité - Universitätsmedizin Berlin","Springer Nature DEAL","no"