id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.format.extent,dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.number,dcterms.bibliographicCitation.url,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eissn,refubium.affiliation,refubium.affiliation.other,refubium.resourceType.isindependentpub,refubium.resourceType.provider "654a51fe-ef23-4173-9642-652948e70f58","fub188/16","Urbański, Arkadiusz||Johnston, Paul||Bittermann, Elisa||Keshavarz, Maryam||Paris, Véronique||Walkowiak-Nowicka, Karolina||Konopińska, Natalia||Marciniak, Paweł||Rolff, Jens","2023-01-17T10:24:14Z","2023-01-17T10:24:14Z","2022","Tachykinins (TKs) are a group of conserved neuropeptides. In insects, tachykinin-related peptides (TRPs) are important modulators of several functions such as nociception and lipid metabolism. Recently, it has become clear that TRPs also play a role in regulating the insect immune system. Here, we report a transcriptomic analysis of changes in the expression levels of immune-related genes in the storage pest Tenebrio molitor after treatment with Tenmo-TRP-7. We tested two concentrations (10–8 and 10–6 M) at two time points, 6 and 24 h post-injection. We found significant changes in the transcript levels of a wide spectrum of immune-related genes. Some changes were observed 6 h after the injection of Tenmo-TRP-7, especially in relation to its putative anti-apoptotic action. Interestingly, 24 h after the injection of 10–8 M Tenmo-TRP-7, most changes were related to the regulation of the cellular response. Applying 10–6 M Tenmo-TRP-7 resulted in the downregulation of genes associated with humoral responses. Injecting Tenmo-TRP-7 did not affect beetle survival but led to a reduction in haemolymph lysozyme-like antibacterial activity, consistent with the transcriptomic data. The results confirmed the immunomodulatory role of TRP and shed new light on the functional homology between TRPs and TKs.","19 Seiten","https://refubium.fu-berlin.de/handle/fub188/37643||http://dx.doi.org/10.17169/refubium-37358","eng","https://creativecommons.org/licenses/by/4.0/","500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie","Antimicrobial responses||Environmental economics||Environmental social sciences","Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.","Wissenschaftlicher Artikel","open access","17277","10.1038/s41598-022-21605-6","Scientific Reports","1","https://doi.org/10.1038/s41598-022-21605-6","12","2045-2322","Biologie, Chemie, Pharmazie","Institut für Biologie:::77195c3c-c355-4e73-837e-d2e0ba8b6c51:::600","no","WoS-Alert"