id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.number,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.pageend,dcterms.bibliographicCitation.pagestart,dcterms.bibliographicCitation.pmid,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eissn,dcterms.isPartOf.issn,refubium.affiliation,refubium.funding,refubium.resourceType.isindependentpub "b55a14fe-392a-4828-9950-08618ca237af","fub188/15","Althoff, Till F.||Garre, Paz||Caixal, Gala||Perea, Rosario||Prat, Susanna||Tolosana, Jose Maria||Guasch, Eduard||Roca‐Luque, Ivo||Arbelo, Elena||Sitges, Marta||Brugada, Josep||Mont, Lluís","2022-11-29T14:53:35Z","2022-11-29T14:53:35Z","2021","Aims: Neither the long-term development of ablation lesions nor the capability of late gadolinium enhancement (LGE)-MRI to detect ablation-induced fibrosis at late stages of scar formation have been defined. We sought to assess the development of atrial ablation lesions over time using LGE-MRI and invasive electroanatomical mapping (EAM). Methods and results: Ablation lesions and total atrial fibrosis were assessed in serial LGE-MRI scans 3 months and >12 months post pulmonary vein (PV) isolation. High-density EAM performed in subsequent repeat ablation procedures served as a reference. Serial LGE-MRI of 22 patients were analyzed retrospectively. The PV encircling ablation lines displayed an average LGE, indicative of ablation-induced fibrosis, of 91.7% ± 7.0% of the circumference at 3 months, but only 62.8% ± 25.0% at a median of 28 months post ablation (p < 0.0001). EAM performed in 18 patients undergoing a subsequent repeat procedure revealed that the consistent decrease in LGE over time was owed to a reduced detectability of ablation-induced fibrosis by LGE-MRI at time-points > 12 months post ablation. Accordingly, the agreement with EAM regarding detection of ablation-induced fibrosis and functional gaps was good for the LGE-MRI at 3 months (κ .74; p < .0001), but only weak for the LGE-MRI at 28 months post-ablation (κ .29; p < .0001). Conclusion: While non-invasive lesion assessment with LGE-MRI 3 months post ablation provides accurate guidance for future redo-procedures, detectability of atrial ablation lesions appears to decrease over time. Thus, it should be considered to perform LGE-MRI 3 months post-ablation rather than at later time-points > 12 months post ablation, like for example, prior to a planned redo-ablation procedure.","https://refubium.fu-berlin.de/handle/fub188/37100||http://dx.doi.org/10.17169/refubium-36814","eng","https://creativecommons.org/licenses/by-nc-nd/4.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","ablation lesions||atrial fibrillation||atrial fibrosis||cardiac MRI||late gadolinium enhancement","Late gadolinium enhancement‐MRI determines definite lesion formation most accurately at 3 months post ablation compared to later time points","Wissenschaftlicher Artikel","open access","10.1111/pace.14415","Pacing and Clinical Electrophysiology","1","Wiley","82","72","34820857","45","1540-8159","0147-8389","Charité - Universitätsmedizin Berlin","DEAL Wiley","no"