id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.number,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.pageend,dcterms.bibliographicCitation.pagestart,dcterms.bibliographicCitation.pmid,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eissn,dcterms.isPartOf.issn,refubium.affiliation,refubium.funding,refubium.resourceType.isindependentpub "4bd4c7d9-15a1-4f5a-bb5c-7f4f16655c0f","fub188/15","Stiglbauer, Victoria||Gamradt, Stefanie||Scherzer, Marie||Brasanac, Jelena||Otte, Christian||Rose, Matthias||Hofmann, Tobias||Hinkelmann, Kim||Gold, Stefan M.","2022-02-15T12:26:53Z","2022-02-15T12:26:53Z","2021","In this pilot study, we explored the immune phenotype of patients with severe obesity and comorbid depressive symptoms compared to non-depressed patients with obesity and normal-weight controls. Immune cell subsets were analysed by flow cytometry and depressive symptoms assessed using the Patient Health Questionnaire (PHQ-9). Cell frequencies were correlated with depressive symptom scores and waist-to-hip ratio (WHR). Patients with obesity and comorbid depression showed significantly lower numbers of circulating cytotoxic natural killer cells, dendritic cells and CD8(+) effector memory T cells, compared to normal-weight controls. Regulatory T cells and CD4(+) central memory T cells were increased compared to non-depressed patients with obesity and compared to normal-weight controls, respectively. Frequencies of cytotoxic natural killer cells and CD4(+) central memory T cells significantly correlated with PHQ-9 scores, but not with WHR. Reduced numbers of dendritic cells were observed in both patient groups with obesity and correlated with PHQ-9 scores and WHR. These findings provide evidence for an altered immune composition in comorbid obesity and depression, supporting a pathobiological overlap between the two disorders.","https://refubium.fu-berlin.de/handle/fub188/34003||http://dx.doi.org/10.17169/refubium-33722","eng","https://creativecommons.org/licenses/by-nc/4.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","depression||immunophenotyping||inflammation||obesity","Immunological substrates of depressive symptoms in patients with severe obesity: An exploratory study","Wissenschaftlicher Artikel","open access","10.1002/cbf.3608","Cell Biochemistry and Function","3","Wiley","431","423","33401342","39","1099-0844","0263-6484","Charité - Universitätsmedizin Berlin","DEAL Wiley","no"