id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.format.extent,dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.url,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eissn,refubium.affiliation,refubium.affiliation.other,refubium.resourceType.isindependentpub,refubium.resourceType.provider "88f28a33-4681-4971-b653-859bdc957eea","fub188/16","Kamble, Nitin||Gurung, Angila||Kaufer, Benedikt B.||Pathan, Ansar Ahmed||Behboudi, Shahriar","2022-02-07T09:43:58Z","2022-02-07T09:43:58Z","2021","Marek’s disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection. However, the exact mechanisms involved in MDV-induced immunosuppression are yet to be identified. Here, our results demonstrate that MDV infection in vitro and in vivo induces activation of cyclooxygenase-2 (COX-2) and production of prostaglandin E2 (PGE2). This exerts its inhibitory effects on T cell proliferation at day 21 post infection via PGE2 receptor 2 (EP2) and receptor 4 (EP4). Impairment of the MDV-induced T cell proliferation was associated with downregulation of IL-2 and transferrin uptake in a COX-2/PGE2 dependent manner in vitro. Interestingly, oral administration of a COX-2 inhibitor, meloxicam, during MDV infection inhibited COX-2 activation and rescued T cell proliferation at day 21 post infection. Taken together, our results reveal a novel mechanism that contributes to immunosuppression in the MDV-infected chickens.","16 Seiten","https://refubium.fu-berlin.de/handle/fub188/33907||http://dx.doi.org/10.17169/refubium-33626","eng","https://creativecommons.org/licenses/by/4.0/","600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche","Marek’s disease virus||T cell proliferation||COX2 = cyclooxygenase 2||PGE2||immunosuppression","Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2","Wissenschaftlicher Artikel","open access","801781","10.3389/fimmu.2021.801781","Frontiers in Immunology","https://doi.org/10.3389/fimmu.2021.801781","12","1664-3224","Veterinärmedizin","Institut für Virologie:::77693aa8-533b-4241-8627-e73e9ce18bc0:::600","no","WoS-Alert"