id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.format.extent,dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.number,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.url,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eissn,refubium.affiliation,refubium.affiliation.other,refubium.note.author[de],refubium.resourceType.isindependentpub "a0995283-5e31-4da1-98d5-a6a31d691808","fub188/16","Midha, Ankur||Goyette-Desjardins, Guillaume||Goerdeler, Felix||Moscovitz, Oren||Seeberger, Peter H.||Tedin, Karsten||Bertzbach, Luca D.||Lepenies, Bernd||Hartmann, Susanne","2021-12-16T13:54:41Z","2021-12-16T13:54:41Z","2021","Ascariasis is a global health problem for humans and animals. Adult Ascaris nematodes are long-lived in the host intestine where they interact with host cells as well as members of the microbiota resulting in chronic infections. Nematode interactions with host cells and the microbial environment are prominently mediated by parasite-secreted proteins and peptides possessing immunomodulatory and antimicrobial activities. Previously, we discovered the C-type lectin protein AsCTL-42 in the secreted products of adult Ascaris worms. Here we tested recombinant AsCTL-42 for its ability to interact with bacterial and host cells. We found that AsCTL-42 lacks bactericidal activity but neutralized bacterial cells without killing them. Treatment of bacterial cells with AsCTL-42 reduced invasion of intestinal epithelial cells by Salmonella. Furthermore, AsCTL-42 interacted with host myeloid C-type lectin receptors. Thus, AsCTL-42 is a parasite protein involved in the triad relationship between Ascaris, host cells, and the microbiota.","17 Seiten","https://refubium.fu-berlin.de/handle/fub188/33174||http://dx.doi.org/10.17169/refubium-32896","eng","https://creativecommons.org/licenses/by/4.0/","500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::579 Mikroorganismen, Pilze, Algen||600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten","Ascaris||helminths||intestinal nematode||microbiota||lectin||Salmonella||glycan array||C-type lectin","Lectin-Mediated Bacterial Modulation by the Intestinal Nematode Ascaris suum","Wissenschaftlicher Artikel","open access","8739","10.3390/ijms22168739","International Journal of Molecular Sciences","16","MDPI","https://doi.org/10.3390/ijms22168739","22","1422-0067","Biologie, Chemie, Pharmazie||Veterinärmedizin","Institut für Immunologie:::e56c4207-7b5a-4453-9998-681575987cd9:::600||Institut für Mikrobiologie und Tierseuchen:::0486de89-b5ff-4b1d-a1dc-692e4750aacf:::600||Institut für Virologie:::77693aa8-533b-4241-8627-e73e9ce18bc0:::600","Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.","no"