id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.identifier.uri,dc.identifier.urn,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.title.translated[de],dc.type,dcterms.accessRights.dnb,dcterms.accessRights.openaire,refubium.affiliation,refubium.resourceType.isindependentpub "bb02e178-ca96-4b3f-a59e-4cadc29aef33","fub188/15","Thronicke, Anja||Schad, Friedemann||Debus, Marion||Grabowski, Jan||Soldner, Georg","2021-06-23T13:48:10Z","2021-06-23T13:48:10Z","2021","Aim: A majority of oncological patients apply add-on white-berry European mistletoe (Viscum album L., VA) extracts to reduce disease- and treatment-related symptoms and to improve health-related quality (HRQL) of life. VA extracts exert various antitumor, pro-apoptotic, anti-proliferative and immunomodulatory effects. Two current meta-analyses attribute life-prolonging and HRQL improving properties to additive VA therapy. The aim of the study was to review the current knowledge on VA extracts in clinical oncology. Methods: 290 clinical research articles including systematic reviews and guidelines were screened and analysed for their association with add-on VA therapy in patients with gynaecological, lung or gastrointestinal cancer. Results: We found a good evidence of add-on VA therapy to improve the HRQL of patients with breast cancer (ASCO-endorsed SIO guideline) and of HRQL-improving and survival-prolonging properties of VA therapy in pancreatic cancer. In the field of gastrointestinal, gynaecological and lung cancer, new or updating integrative and/or oncological guidelines should consider clear recommendations on integrative therapies including VA therapy. Nevertheless, further clinical and real-world data trials need to be performed in this field. Conclusion: The present update provides a brief overview regarding the use of VA preparations in clinical oncology reviewing current systematic reviews, randomized controlled and real-world data studies. In addition, current guidelines as to their suggestions in the context of VA therapy are highlighted as evidence in the improved management of cancer and cancer-related side effects for this treatment is accumulating.","https://refubium.fu-berlin.de/handle/fub188/31079||http://dx.doi.org/10.17169/refubium-30815","urn:nbn:de:kobv:188-refubium-31079-3","eng","https://creativecommons.org/licenses/by/4.0/","600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit","VA extracts||VA therapy||oncology||integrative oncology||guidelines","Viscum album L. therapy in oncology – an update on current evidence","Viscum album L. Therapie in der Onkologie - ein Update der aktuellen Evidenz","Preprint","free","open access","Charité - Universitätsmedizin Berlin","no"