id,collection,dc.contributor.author,dc.date.accessioned,dc.date.available,dc.date.issued,dc.description.abstract[en],dc.format.extent,dc.identifier.uri,dc.language,dc.rights.uri,dc.subject.ddc,dc.subject[en],dc.title,dc.type,dcterms.accessRights.openaire,dcterms.bibliographicCitation.articlenumber,dcterms.bibliographicCitation.doi,dcterms.bibliographicCitation.journaltitle,dcterms.bibliographicCitation.number,dcterms.bibliographicCitation.originalpublishername,dcterms.bibliographicCitation.url,dcterms.bibliographicCitation.volume,dcterms.isPartOf.eissn,refubium.affiliation,refubium.affiliation.other,refubium.resourceType.isindependentpub "8426f49f-1138-46ea-ad70-e782275e59de","fub188/16","Rajes, Keerthana||Walker, Karolina A.||Hadam, Sabrina||Zabihi, Fatemeh||Rancan, Fiorenza||Vogt, Annika||Haag, Rainer","2021-02-18T11:16:47Z","2021-02-18T11:16:47Z","2020","A synthetic route for redox-sensitive and non-sensitive core multi-shell (CMS) carriers with sizes below 20 nm and narrow molecular weight distributions was established. Cyclic voltammetric measurements were conducted characterizing the redox potentials of reduction-sensitive CMS while showcasing its reducibility through glutathione and tris(2-carboxyethyl)-phosphine as a proof of concept. Measurements of reduction-initiated release of the model dye Nile red by time-dependent fluorescence spectroscopy showed a pronounced release for the redox-sensitive CMS nanocarrier (up to 90% within 24 h) while the non-sensitive nanocarriers showed no release in PBS. Penetration experiments using ex vivo human skin showed that the redox-sensitive CMS nanocarrier could deliver higher percentages of the loaded macrocyclic dye meso-tetra (m-hydroxyphenyl) porphyrin (mTHPP) to the skin as compared to the non-sensitive CMS nanocarrier. Encapsulation experiments showed that these CMS nanocarriers can encapsulate dyes or drugs with different molecular weights and hydrophobicity. A drug content of 1 to 6 wt% was achieved for the anti-inflammatory drugs dexamethasone and rapamycin as well as fluorescent dyes such as Nile red and porphyrins. These results show that redox-initiated drug release is a promising strategy to improve the topical drug delivery of macrolide drugs.","15 Seiten","https://refubium.fu-berlin.de/handle/fub188/29680||http://dx.doi.org/10.17169/refubium-29424","eng","https://creativecommons.org/licenses/by/4.0/","500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften||600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten||600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik","CMS nanocarriers||disulfide||redox||stimuli responsive||cyclic voltammetry||skin penetration||rapamycin||dexamethasone","Redox-Responsive Nanocarrier for Controlled Release of Drugs in Inflammatory Skin Diseases","Wissenschaftlicher Artikel","open access","37","10.3390/pharmaceutics13010037","Pharmaceutics","1","MDPI","https://doi.org/10.3390/pharmaceutics13010037","13","1999-4923","Biologie, Chemie, Pharmazie","Institut für Chemie und Biochemie:::bdaf1c47-f341-464f-b012-0d24067d34b8:::600","no"